Exploring the clinical characteristics and prevalence of the annular pancreas: a meta-analysis.

BACKGROUND: The annular pancreas (AP) is a rare gastrointestinal congenital malformation, in which malrotation of the pancreatic ventral bud in the seventh week of embryonic development manifests in a partial or complete ring of tissue around the second part of the duodenum. METHODS: The main online medical databases such as PubMed, ScienceDirect, Wiley online library, Web of Science, and EBSCO discovery service were used to gather all relevant studies on the AP. RESULTS: A total of 12,729,118 patients were analyzed in relation to the prevalence of AP. The pooled prevalence of AP was 0.0045% (95% CI: 0.0021%-0.0077%). The most frequent comorbidity in adults and children was duodenal obstruction, with a pooled prevalence of 24.04% and 52.58%, respectively (95% CI: 6.86%-46.48% and 35.56%-69.31%, respectively). The most frequent operation in adult patients with AP was duodenojejunostomy, with pooled prevalence established at 3.62% (95% CI: 0.00%-10.74%). CONCLUSION: The diagnostic complexity of AP is accentuated by its nonspecific clinical symptoms, making accurate identification reliant on imaging studies. Therefore, having a thorough knowledge of the clinical characteristics of the AP and its associated anomalies becomes paramount when faced with this rare congenital condition.

Transcriptomic analysis of the signature of neurogenesis in human hippocampus suggests restricted progenitor cell progression post-childhood.

PURPOSE: Immunohistological investigations have given rise to divergent perspectives about adult hippocampal neurogenesis in humans. Therefore, this study aimed to examine whether a comprehensive transcriptomic analysis of signature markers of neurogenesis, supplemented with markers of gliogenesis, vasculogenesis, cell proliferation, and apoptosis, may help discern essential aspects of adult hippocampal neurogenesis in humans. MATERIALS AND METHODS: RNA expression data for salient marker genes of neurogenesis, gliogenesis, vasculogenesis, and apoptosis in post-mortem human hippocampal tissue [from prenatal (n = 15), child (n = 5), adolescent (n = 4), and adult (n = 6) brains] were downloaded from the Allen Human Brain Atlas database (http://www.brainspan.org/rnaseq/search/index.html). Gene expression data was categorized, median values were computed, and age group-specific differential expression was subjected to statistical analysis (significance level, α = 0.01). RESULTS: With the exception of the genes encoding GFAP, BLBP, SOX2, and PSA-NCAM (unchanged), and the post-mitotic late maturation markers CALB1, CALB2, MAP2, and NEUN as well as the pan-neuronal marker PROX1 which were persistently expressed throughout, expression of all other genes associated with neurogenesis was steeply and progressively downregulated between perinatal life and adulthood. Interestingly, expression of the classical proliferation marker KI67 and a progenitor cell marker TBR2 were found to have reached baseline expression levels (zero expression score) at adolescence while the expression of immature neuronal, post-mitotic early and late maturation markers remained at a constant level after childhood. In contrast, markers of gliogenesis (other than PDGFRA and Vimentin) were significantly upregulated between prenatal life and childhood. Expression of the vasculogenesis markers VEGFA and FGF2 did not differ across any of the age groups studied, whereas the expression of apoptotic markers was progressively decreased after prenatal life. CONCLUSIONS: Our findings indicate that the progression of neurogenesis from progenitor cells is highly restricted in the human brain from childhood onwards. An alternative possibility that limited neurogenesis may be continued in adolescents and adults from a developmentally arrested pool of immature neurons needs to be examined further through experimental studies.

ADULT NEUROGENESIS IN HUMANS: A Review of Basic Concepts, History, Current Research, and Clinical Implications.

Neurogenesis in adult humans remains a controversial area of research among neuroscientists. Methodological challenges have hampered investigators from conducting high-quality, in-vivo studies that can help elucidate the presence and/or activity of neurogenesis in human brains. Additionally, the studies that have been done in humans report conflicting results, further adding to the ambiguity surrounding the concept of adult neurogenesis in humans. In this review article, the authors seek to help clarify the concept of adult neurogenesis by providing an overview of the basic concept, as we currently understand it, including its historical birth and evolution. The authors also review and discuss current key studies (pro and con) on adult neurogenesis in humans and animals, as well as research challenges with potential solutions. Finally, the authors discuss the clinical implications of adult neurogenesis in humans, based on what we know so far, including its potential use as a drug target in the development of pharmacological treatments for various neuropsychiatric disorders.

Marcello Malpighi (1628-1694): Pioneer of microscopic anatomy and exponent of the scientific revolution of the 17th Century

Marcello Malpighi (1628-1694) was an Italian anatomist and an eminent scientist who significantly contributed to the advancement of the anatomical sciences in the 17th century. Malpighi was one of the first to use the compound microscope (an instrument designed by Galileo in 1609) and made the most important discovery of his life in 1661 when he identified capillaries as connecting vessels between small arteries and veins in the lungs. Malpighi thus provided the missing link in William Harvey's theory of blood circulation. He made significant contributions in the field of embryology based on his observations on chick embryo, and his efforts provided deep insights into the development of the heart and the nervous system. His communications based on microscopic studies scripted valuable details on the structural organization of organs like the liver, kidney and spleen. He identified the hepatic lobule as the fundamental unit of the liver and noted that bile was being secreted by these lobules and not from the gall bladder (the popular belief then). In the kidney he discovered the glomerulus (Malpighian Corpuscle), and was the first to observe the convoluted tubules in the renal cortex. He was the first to describe the presence of lymphatic bodies (Malpighi's Corpuscle) in the spleen. Although he was exceedingly successful in his scientific activities, his life was fraught with unfortunate events and savage criticism from detractors arising out of professional jealousy and personal feuds. Nevertheless his exploits were instrumental in understanding the human microscopic anatomy (histology) and his accomplishments have etched his name in the pages of medical science forever

No disponible

Henri de Mondeville (1260-1320): Medieval French Anatomist and Surgeon

Henri de Mondeville (1260-1320) was a French anatomist and surgeon. He was surgeon to King Philip the Fair of France and his successor Louis X. He belonged to an elite class of surgeons, the médecins-chirugiens, who were graduates of a medical school as well as holders of a Master’s Degree, and were held in high esteem in the practice of surgery. He served as Professor of Anatomy and Surgery at the University of Montpellier between 1301 and 1304. He was a visionary anatomist, who taught the subject from a series of handmade, full-length illustrations, which, though rudimentary in terms of precise anatomical knowledge, marked a significant transformation in anatomical studies during those days, as human cadaveric dissection was prohibited and anatomists had to rely solely on textual descriptions prevalent from the ancient period. Mondeville conducted the first unauthorized human dissection at the University of Montpellier in 1315, and his efforts were pivotal towards legalization of human dissection in France from 1340. He was the first Frenchman to author a surgical text, La Chirurgie, which he could not complete due to his untimely death. Mondeville introduced the concept of aseptic management of wounds without inducing pus formation, and successfully applied the same on injured soldiers. However neither his contemporaries nor his immediate successors recognized the value of his work, which gradually went into oblivion, only to be rediscovered centuries later with the revival of antiseptic surgery in modern times

No disponible

Screening for pulmonary arterial hypertension in patients with scleroderma--a New Zealand perspective.

BACKGROUND: Pulmonary arterial hypertension (PAH) in scleroderma (SSc) patients is a devastating complication with high mortality if untreated. Early recognition and specific treatment of PAH may improve outcome. Regular interval screening for PAH is generally recommended in scleroderma patients especially with the availability of emerging new therapies. The aim of this study is to determine the self-reported screening and treatment practices for SSc-PAH amongst rheumatologists in New Zealand (NZ). METHODS: An anonymous online questionnaire survey was emailed to all rheumatologists in New Zealand. RESULTS: Responses were received from 65% (39/60) of rheumatologists. The majority of patients had limited SSc (lcSSc) (57%) versus diffuse SSc (dcSSc) (34%). Twelve percent of patients had PAH. Eighty-two percent of rheumatologists screened for PAH in all SSc patients regardless of symptoms. The most commonly used screening modalities were pulmonary function tests (PFT) (97%) followed by clinical examination (95%) and echocardiogram (TTE) (92%). The majority of rheumatologists performed screening tests on a yearly basis (80% used PFT and 64% used TTE). A right heart catheter was used to confirm PAH in 70% of patients. Sixty-four percent of rheumatologists extend screening interval time if their patients were clinically stable. The most common PAH-specific therapy used was sildenafil (57%) followed by bosentan (19%). Sixty-four percent of rheumatologists supported a national PAH-SSc screening guideline. CONCLUSION: This study has shown a wide variability of how NZ rheumatologists screen for PAH in scleroderma patients. The development of a PAH-SSc guideline for screening and diagnosis may help standardise treatment practices in NZ.